Manuscript Number : IJSRST2296105

Calcium Signaling in Neurodegeneration : A Review

Authors(1) :-Rijul Mahesh Kharat

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and spinocerebellar ataxias (SCAs), pose a significant medical, social, financial, and scientific challenge. Recent data suggests that many of these illnesses have aberrant neuronal calcium (Ca2+) transmission. Normal aging causes alterations in neuronal Ca2+ signaling that are similar but less drastic. Here, we address the dysregulation of calcium in a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Also noted is the potential effectiveness of Ca2+ blockers in the treatment of various illnesses.

Authors and Affiliations

Rijul Mahesh Kharat
Hiranandani Foundation School Powai, Mumbai, Maharashtra, India

Calcium Signaling, Dysregulation of calcium, Alzheimer's disease, Parkinson's disease, Huntington's disease, Calcium Blockers

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  2. Ekaterina Pchitskaya, Elena Popugaeva, and Ilya Bezprozvanny, “Calcium signaling and molecular mechanisms underlying neurodegenerative diseases,"  Cell Calcium  http://dx.doi.org/10.1016/j.ceca.2017.06.008
  3. Rodrigo Portes Ureshino, Adolfo Garcia Erustes, Taysa Bervian Bassani, Patrícia Wachilewski, Gabriel Cicolin Guarache, Ana Carolina Nascimento, Angelica Jardim Costa, Soraya Soubhi Smaili and, Gustavo José da Silva Pereira, “The Interplay between Ca2+ signaling pathways and neurodegeneration”, Int. J. Mol. Sci. 2019, 20(23), 6004; https://doi.org/10.3390/ijms20236004
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  6. Demuro, Ian Parker, Grace E. Stutzmann, “ Calcium Signaling and Amyloid Toxicity in Alzheimer Disease," in Journal of Biological Chemistry  VOLUME 285, ISSUE 17, P12463-12468, APRIL 2010.
  7. Temitope Adeoye, Syed I Shah, Angelo Demuro, David A Rabson, and Ghanim Ullah, “Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer's Disease” in the National Library of Medicine, 2022 Jul 11;11(14):2167. Doi: 10.3390/cells11142167.
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Publication Details

Published in : Volume 10 | Issue 1 | January-February 2023
Date of Publication : 2023-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 113-120
Manuscript Number : IJSRST2296105
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Rijul Mahesh Kharat, " Calcium Signaling in Neurodegeneration : A Review", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 10, Issue 1, pp.113-120, January-February-2023. Available at doi : https://doi.org/10.32628/IJSRST2296105    
Journal URL : https://ijsrst.com/IJSRST2296105
Citation Detection and Elimination     |      | | Ilya Bezprozvanny, “Calcium signaling and neurodegenerative diseases”, in Trends in Molecular Medicine journal, Vol.15, No.3, doi:10.1016/j.molmed.2009.01.001
  • Ekaterina Pchitskaya, Elena Popugaeva, and Ilya Bezprozvanny, “Calcium signaling and molecular mechanisms underlying neurodegenerative diseases,"  Cell Calcium  http://dx.doi.org/10.1016/j.ceca.2017.06.008
  • Rodrigo Portes Ureshino, Adolfo Garcia Erustes, Taysa Bervian Bassani, Patrícia Wachilewski, Gabriel Cicolin Guarache, Ana Carolina Nascimento, Angelica Jardim Costa, Soraya Soubhi Smaili and, Gustavo José da Silva Pereira, “The Interplay between Ca2+ signaling pathways and neurodegeneration”, Int. J. Mol. Sci. 2019, 20(23), 6004; https://doi.org/10.3390/ijms20236004
  • I.B.Bezprozvanny,”Calcium Signaling and Neurodegenration”, in Acta Naturae, vol. 2, 2010
  • Marambaud, Ute Dreses-Werringloer &, Valérie Vingtdeux, “Calcium signaling in neurodegeneration” in Molecular Neurodegeneration Article number: 20 (2009)
  • Demuro, Ian Parker, Grace E. Stutzmann, “ Calcium Signaling and Amyloid Toxicity in Alzheimer Disease," in Journal of Biological Chemistry  VOLUME 285, ISSUE 17, P12463-12468, APRIL 2010.
  • Temitope Adeoye, Syed I Shah, Angelo Demuro, David A Rabson, and Ghanim Ullah, “Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer's Disease” in the National Library of Medicine, 2022 Jul 11;11(14):2167. Doi: 10.3390/cells11142167.
  • Tomoyuki Takahashi & Akiko Momiyama, “Different types of calcium channels mediate central synaptic transmission,"  in Nature, 366, 156–158 (1993). https://doi.org/10.1038/366156a0 volum 4, Article number: 20 (2009)
    • " target="_blank"> BibTeX     | Ilya Bezprozvanny, “Calcium signaling and neurodegenerative diseases”, in Trends in Molecular Medicine journal, Vol.15, No.3, doi:10.1016/j.molmed.2009.01.001
  • Ekaterina Pchitskaya, Elena Popugaeva, and Ilya Bezprozvanny, “Calcium signaling and molecular mechanisms underlying neurodegenerative diseases,"  Cell Calcium  http://dx.doi.org/10.1016/j.ceca.2017.06.008
  • Rodrigo Portes Ureshino, Adolfo Garcia Erustes, Taysa Bervian Bassani, Patrícia Wachilewski, Gabriel Cicolin Guarache, Ana Carolina Nascimento, Angelica Jardim Costa, Soraya Soubhi Smaili and, Gustavo José da Silva Pereira, “The Interplay between Ca2+ signaling pathways and neurodegeneration”, Int. J. Mol. Sci. 2019, 20(23), 6004; https://doi.org/10.3390/ijms20236004
  • I.B.Bezprozvanny,”Calcium Signaling and Neurodegenration”, in Acta Naturae, vol. 2, 2010
  • Marambaud, Ute Dreses-Werringloer &, Valérie Vingtdeux, “Calcium signaling in neurodegeneration” in Molecular Neurodegeneration Article number: 20 (2009)
  • Demuro, Ian Parker, Grace E. Stutzmann, “ Calcium Signaling and Amyloid Toxicity in Alzheimer Disease," in Journal of Biological Chemistry  VOLUME 285, ISSUE 17, P12463-12468, APRIL 2010.
  • Temitope Adeoye, Syed I Shah, Angelo Demuro, David A Rabson, and Ghanim Ullah, “Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer's Disease” in the National Library of Medicine, 2022 Jul 11;11(14):2167. Doi: 10.3390/cells11142167.
  • Tomoyuki Takahashi & Akiko Momiyama, “Different types of calcium channels mediate central synaptic transmission,"  in Nature, 366, 156–158 (1993). https://doi.org/10.1038/366156a0 volum 4, Article number: 20 (2009)
    • " target="_blank">RIS     | Ilya Bezprozvanny, “Calcium signaling and neurodegenerative diseases”, in Trends in Molecular Medicine journal, Vol.15, No.3, doi:10.1016/j.molmed.2009.01.001
  • Ekaterina Pchitskaya, Elena Popugaeva, and Ilya Bezprozvanny, “Calcium signaling and molecular mechanisms underlying neurodegenerative diseases,"  Cell Calcium  http://dx.doi.org/10.1016/j.ceca.2017.06.008
  • Rodrigo Portes Ureshino, Adolfo Garcia Erustes, Taysa Bervian Bassani, Patrícia Wachilewski, Gabriel Cicolin Guarache, Ana Carolina Nascimento, Angelica Jardim Costa, Soraya Soubhi Smaili and, Gustavo José da Silva Pereira, “The Interplay between Ca2+ signaling pathways and neurodegeneration”, Int. J. Mol. Sci. 2019, 20(23), 6004; https://doi.org/10.3390/ijms20236004
  • I.B.Bezprozvanny,”Calcium Signaling and Neurodegenration”, in Acta Naturae, vol. 2, 2010
  • Marambaud, Ute Dreses-Werringloer &, Valérie Vingtdeux, “Calcium signaling in neurodegeneration” in Molecular Neurodegeneration Article number: 20 (2009)
  • Demuro, Ian Parker, Grace E. Stutzmann, “ Calcium Signaling and Amyloid Toxicity in Alzheimer Disease," in Journal of Biological Chemistry  VOLUME 285, ISSUE 17, P12463-12468, APRIL 2010.
  • Temitope Adeoye, Syed I Shah, Angelo Demuro, David A Rabson, and Ghanim Ullah, “Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer's Disease” in the National Library of Medicine, 2022 Jul 11;11(14):2167. Doi: 10.3390/cells11142167.
  • Tomoyuki Takahashi & Akiko Momiyama, “Different types of calcium channels mediate central synaptic transmission,"  in Nature, 366, 156–158 (1993). https://doi.org/10.1038/366156a0 volum 4, Article number: 20 (2009)
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