Manuscript Number : IJSRST184163

In-Silico Molecular Characterization of MST1 Protein

Authors(3) :-Vinod P. Sinoorkar, Pratiksha Thakurdas, Reshma Ghodake

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Diabetes cases up to 422 million worldwide; India ranks among top 3 countries with diabetic population. Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced. Two distinct mechanisms are responsible for the death of ? cells one through ER stress induced death and the other being cytokine mediated death via apoptosis. Various literature and the molecular pathways emphasizes the involvement of one major protein for ? cell death named as MST-1. Mammalian Sterile-20-like kinase (MST1, also known as STK4, KRS2) is an ubiquitously expressed serine/threonine kinase, it is part of the Hippo signaling pathway and involved in multiple cellular processes such as morphogenesis, proliferation, stress response and apoptosis. Hence our present investigations focus mainly to understand the detailed molecular features of MST-1 by retrieving its protein sequence from major protein sequence repository, analysing the physico-chemical properties, secondary structural elements and tertiary structure prediction using various databases, tools and techniques of bioinformatics.

Authors and Affiliations

Vinod P. Sinoorkar
Walchand Centre for Biotechnology, Walchand College of Arts and Science, Solapur, Maharashtra, India
Pratiksha Thakurdas
Walchand Centre for Biotechnology, Walchand College of Arts and Science, Solapur, Maharashtra, India
Reshma Ghodake
Walchand Centre for Biotechnology, Walchand College of Arts and Science, Solapur, Maharashtra, India

Diabetes Mellitus, β Cell Death, STK4, KRS2, MST1 Protein.

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Publication Details

Published in : Volume 4 | Issue 2 | January-February 2018
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 542-546
Manuscript Number : IJSRST184163
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Vinod P. Sinoorkar, Pratiksha Thakurdas, Reshma Ghodake, " In-Silico Molecular Characterization of MST1 Protein", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 2, pp.542-546, January-February-2018.
Journal URL : https://ijsrst.com/IJSRST184163
Citation Detection and Elimination     |      | |"Protein Information Resource: A community resource for expert annotation of protein data". Nucleic Acids Research. 29 (1): 29?32. doi:10.1093/nar/29.1.29. PMC 29802. PMID 11125041.
  • Gobel, U.; et al. (1994). "Correlated mutations and residue contacts in proteins". Proteins. 18 (4): 309?17. doi:10.1002/prot.340180402. PMID 8208723.
  • Gettins PG (2002). "Serpin structure, mechanism, and function". ChemRev. 104751804. doi:10.1021/cr010170.
  •  PMID 12475206 Kitabchi, AE; Umpierrez, GE; Miles, JM; Fisher, JN (Jul 2009). "Hyperglycemic crises in adult patients withdiabetes.". DiabetesCare. 32 (7):1335?43. doi:10.2337/dc09-9032. PMC 2699725. PMID 19564476
  • Pirovano, W.; Heringa, J. (2010). "Protein secondary structure prediction". Methods Mol Biol. Methods in Molecular Biology. 609: 327?48. doi:10.1007/978-1-60327-241-4_19. ISBN 978-1-60327-240-7. PMID 20221928.
  • William L. Masterton, Cecile N. Hurley, "Chemistry: Principles and Reactions", 6th edition.? Brooks/ColeCengage Learning, 2009, p.13 (Google books)
  • Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J.Biol. Chem. 271 (15): 9024?32. doi:10.1074/jbc.271.15.9024. PMID 8621550
    • " target="_blank"> BibTeX | "Protein Information Resource: A community resource for expert annotation of protein data". Nucleic Acids Research. 29 (1): 29?32. doi:10.1093/nar/29.1.29. PMC 29802. PMID 11125041.
  • Gobel, U.; et al. (1994). "Correlated mutations and residue contacts in proteins". Proteins. 18 (4): 309?17. doi:10.1002/prot.340180402. PMID 8208723.
  • Gettins PG (2002). "Serpin structure, mechanism, and function". ChemRev. 104751804. doi:10.1021/cr010170.
  •  PMID 12475206 Kitabchi, AE; Umpierrez, GE; Miles, JM; Fisher, JN (Jul 2009). "Hyperglycemic crises in adult patients withdiabetes.". DiabetesCare. 32 (7):1335?43. doi:10.2337/dc09-9032. PMC 2699725. PMID 19564476
  • Pirovano, W.; Heringa, J. (2010). "Protein secondary structure prediction". Methods Mol Biol. Methods in Molecular Biology. 609: 327?48. doi:10.1007/978-1-60327-241-4_19. ISBN 978-1-60327-240-7. PMID 20221928.
  • William L. Masterton, Cecile N. Hurley, "Chemistry: Principles and Reactions", 6th edition.? Brooks/ColeCengage Learning, 2009, p.13 (Google books)
  • Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J.Biol. Chem. 271 (15): 9024?32. doi:10.1074/jbc.271.15.9024. PMID 8621550
    • " target="_blank">RIS | "Protein Information Resource: A community resource for expert annotation of protein data". Nucleic Acids Research. 29 (1): 29?32. doi:10.1093/nar/29.1.29. PMC 29802. PMID 11125041.
  • Gobel, U.; et al. (1994). "Correlated mutations and residue contacts in proteins". Proteins. 18 (4): 309?17. doi:10.1002/prot.340180402. PMID 8208723.
  • Gettins PG (2002). "Serpin structure, mechanism, and function". ChemRev. 104751804. doi:10.1021/cr010170.
  •  PMID 12475206 Kitabchi, AE; Umpierrez, GE; Miles, JM; Fisher, JN (Jul 2009). "Hyperglycemic crises in adult patients withdiabetes.". DiabetesCare. 32 (7):1335?43. doi:10.2337/dc09-9032. PMC 2699725. PMID 19564476
  • Pirovano, W.; Heringa, J. (2010). "Protein secondary structure prediction". Methods Mol Biol. Methods in Molecular Biology. 609: 327?48. doi:10.1007/978-1-60327-241-4_19. ISBN 978-1-60327-240-7. PMID 20221928.
  • William L. Masterton, Cecile N. Hurley, "Chemistry: Principles and Reactions", 6th edition.? Brooks/ColeCengage Learning, 2009, p.13 (Google books)
  • Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J.Biol. Chem. 271 (15): 9024?32. doi:10.1074/jbc.271.15.9024. PMID 8621550
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