Manuscript Number : IJSRST185215

Exploring Anti-Inflammatory Potential in Leaves of Jamun (Syzygium Cumini)

Authors(7) :-Pooja Patil, Kanchan Magar, Twinkle Bansode, Amit Gupta, Sushma Chaphalkar, Ashok Patil, Anant Sherkhane

Inflammation is initiated as healing process by the tissue in response to injury by pathogens, irritants or cell damage. Anti-inflammatory drugs used today to cure the disease have serious side-effects. The focus of research is to study the bioactive compounds from medicinal plants with anti-inflammatory property. The work is carried out with Syzygium cumini leaves (family-Myrtaceae). Leaves are reported to posses anti-inflammatory activity in crude extract of leaves and bark. In our study, ethanolic extract of leaves was screened for the anti-inflamatory activity and bioactive compound was partially purified by Thin Layer Chromatography (TLC) technique. Partially purified bioactive compounds were further analysed using various in vitro models such as inhibition of albumin denaturation assay and HRBC membrane stabilization assay. Aspirin and diclofenac sodium were used as standard drug. It is cleared from the result that the bioactive compound tannins at concentration of 100?g/ml posses 99.50% inhibition of heat induced protein denaturation as compared with the standard drug Aspirin i.e. 89.26%. In HRBC membrane stabilization activity tannins at concentration of 1mg/ml showed 82.94% protection of HRBC membrane while the standard diclofenac sodium showed 70.41% protection. Overall study claims that ethanol extract of S. cumini leaves posses potential anti-inflamatory activity due. Further study is required to purify and identify the specific bioactive compound.

Authors and Affiliations

Pooja Patil
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India
Kanchan Magar
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India, Pravara Institute of Medical Sciences (DU), Loni (Bk), Tal. Rahata, Dist. Ahmednagar, Maharashtra, India
Twinkle Bansode
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India
Amit Gupta
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India
Sushma Chaphalkar
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India
Ashok Patil
Vidya Prathishtan’s School of Biotechnology (VSBT), Baramati, Maharashtra, India
Anant Sherkhane

Herbal preparation, Bioactive compounds, S. Cumini, TLC, Aspirin, Diclofenac sodium

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Publication Details

Published in : Volume 5 | Issue 2 | January-February 2018
Date of Publication : 2018-02-03
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 90-96
Manuscript Number : IJSRST185215
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Pooja Patil, Kanchan Magar, Twinkle Bansode, Amit Gupta, Sushma Chaphalkar, Ashok Patil, Anant Sherkhane, " Exploring Anti-Inflammatory Potential in Leaves of Jamun (Syzygium Cumini)", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 5, Issue 2, pp.90-96, January-February-2018.
Journal URL : https://ijsrst.com/IJSRST185215
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